Circulating microRNAs Related to Bone Metabolism in HIV-Associated Bone Loss
نویسندگان
چکیده
منابع مشابه
Regulation of Bone Metabolism
Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation,...
متن کاملGrowing Rats Are Resistant to Bone Loss Associated With Short-Term Hypercholesterolemia: A Preliminary Experimental Study
We aimed to evaluate the potential of growing rats as a model of osteoporosis induced by short term hypercholesterolemia. Twelve growing female Sprague-Dawley rats were randomly allocated into two groups. Control rats received standard diet while rats in group 2 were fed with diet contained 20% sunflower oil, 2% cholesterol and 0.5% cholic acid for 2 weeks and then a diet contained 10% sunflowe...
متن کاملBone Metabolism and HIV Infection
Osteoporosis (OP) is the most widely spread metabolic osteopathy in the Western world, and is defined as a generalised state of the skeletal structure, characterised by a low bone mass and microarchitectural alterations, with an increase in bone fragility and risk of fracture (1). OP is now considered as an evolutive disorder affecting both the mineral and organic components leading to a progre...
متن کاملThe protease inhibitors and HIV-associated bone loss.
PURPOSE OF REVIEW HIV infection is an established risk factor for osteoporosis and bone fracture. Combination antiretroviral therapy (cART) increases bone resorption leading to an additional 2-6% bone mineral density (BMD) loss within the first 1-2 years of therapy. Although tenofovir disoproxil fumarate is often blamed for antiretroviral drug-associated bone loss, evidence abounds to suggest t...
متن کاملCirculating microRNAs Correlated with Bone Loss Induced by 45 Days of Bed Rest
The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with bone loss induced by bed rest, and testify whether the selected miRNAs could reflect the bone mineral status of human after bed-rest. We analyzed plasma miRNA levels of 16 subjects after 45 days of -6° head-down tilt bed rest, which is a reliable model for the simulation of microgravity. We characterize the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomedicines
سال: 2021
ISSN: 2227-9059
DOI: 10.3390/biomedicines9040443